High-throughput Chemistry
Pharmaron’s high-throughput chemistry service has the flexibility to provide large compound libraries for compound collection enhancement and screening as well as small, focused libraries for lead optimization. We are proficient in the construction of solution or solid phase libraries.
Recent projects:
Hit to Lead Project Example:
- Number of libraries: 11
- Synthetic steps: 8-11 steps
- Number of compounds: 215
- Quantity of each compound: 25 mg
- Purity: at least 90% & purified by HPLC
- Analytical data: LCMS for all & selected NMR
- Delivery format: Dry form in bar-coded vials
- Delivery time: 3 months
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Lead Optimization Project Example:
- Number of libraries: 7
- Synthetic steps: 6-10 steps
- Number of compounds: 588
- Quantity of each compound: 20 mg
- Purity: at least 90% & purified by HPLC
- Analytical data: LCMS for all & selected NMR
- Delivery format: Dry form in bar-coded vials
- Delivery time: 3 months
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