In Vitro Toxicology
Genotoxicity
- AMES assays: Liquid based, 4 strains: TA97, 98, 100, 102 (medium throughput, for discovery phase)
- AMES assays: Plate based
- Comet assay
- HPRT
- Micronucleus assay
Cytotoxicity (MTT, MTS, Alamar blue)
Cardiac toxicity
- hERG assays
- Fluorescence polarization (FP) assay
- Cell based FluxORTM thallium detection
- Radioligand binding assay
- Patch-clamp electrophysiology