In vitro Toxicity

  Biology Services Sheet

• AMES assays: Liquid based, 4-5 strains: TA97, 98, 100, 102 (medium throughput, for discovery phase)
• AMES assays: Plate based
• HPRT
• Comet assay
• In Vitro chromosomal aberration assay
• In Vitro micronucleus assay

• MTT
• MTS
• XTT
• Alamar blue 

• hERG assays
  • Manual patch-clamp electrophysiology
  • Cell-based fluorecence assays (FluxOR or Membrane potential)
  • Fluorescence polarization (FP) assay
  • Radioligand binding assay