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Lead Optimization
- SAR development based on in vitro biology and ADMET
- Conduct metabolic profiling and improve PK in rodent
- Achieve in vivo PK criteria
- Achieve in vivo efficacy with appropriate disease models including PK/PD correlation
- Achieve acceptable rodent tox and safety pharmacology profile
- Conduct process chemistry/scale up, pre-formulation and formulation studies
- Patent filing
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