Metabolite ID
Screening/identification of metabolites for a drug candidate is an important step in the drug discovery and development process.
In vitro models available:
- Liver microsomes, S9, hepatocytes, plasma (species: mouse, rat, dog and human).
Service options:
- LC-MS metabolite profiling
- Summary of materials and methods;
- Ion chromatogram of parent and proposed metabolites;
- List of proposed metabolite molecular weights and molecular formula.
- LC-MS-MS metabolite profiling
- MS/MS spectra of parent and proposed metabolites;
- Detailed information on the formation of the major metabolites.
- Metabolite characterization
- Hypothesis of metabolite structures supported by spectra obtained in various mass spectrometric scans (neutral loss scan, precursor ion scan and product ion scan).