Services

Pharmaron's mission is to provide the highest quality R&D services while helping our customers advance their projects in a timely and cost effective manner.

• Chemistry: In addition to our strong synthetic chemistry team with exceptional skill in heterocyclic chemistry, Pharmaron has expertise in ch iral chemistry (asymmetric chemical & enzymatic reactions) and bioorganic chemistry including nucleosides & nucleotides, carbohydrates, lipid & PEGylation chemistry.

• Biology: Pharmaron biology provides a broad spectrum of high quality services to support various stages of drug discovery and development.  With strong training in biochemistry, molecular and cellular biology, our teams are highly experienced, and focused on customer assay development, compound evaluation using cell-free biochemical assays, cell culture models, biomarker discovery and in vitro toxicology.

• DMPK:  Pharmaron o ffers a comprehensive panel of in vitro ADME assays including solubility, metabolic stability (microsomes, liver S9 fraction, hepatocytes), permeability, plasma protein binding, and Cyp inhibition.  We are experienced conducting in vivo PK a nd BBB studies.

• Pharmacology: Pharmaron’s pharmacology team includes world-class scientists and has extensive experience in the field of oncology.  A large collection of tumor cell lines and fresh tumor tissue samples, together with validated in vivo tumor models, allows us to support clients’ drug discovery programs to lead optimization.

• Chemical Development and Manufacturing: Our experienced chemical development group routinely designs and discovers new scaleable routes, optimize existing routes for quick scale up as well as develop manufacturing routes.  We have the experti se and equipment to prepare compounds from gram to hundreds of kilograms scales. We can provide GMP manufacturing of drug substances (API) on the kilogram scale as well.

• Integrated Services: Pharmaron offers comprehensive services in all areas of drug R&D.  Our ability to bring the groups together in a single project allows us to provide quality integrated R&D services.