Safety Pharmacology

  In vivo Pharmacology Service Sheet

  Preclinical Services Sheet

Safety pharmacology studies are designed to investigate effects of test articles on vital functions in mammalian species. Primary evaluations include cardiovascular, respiratory, and central nervous system assessment. Supplemental evaluations of renal/urinary function, gastrointestinal function, and immune function may also be performed. The following types of safety pharmacology studies, in both large and small animal species, are conducted in compliance with GLP regulations, specifically stand-alone or combined and/or incorporated with toxicology studies:

Core Battery Tests - Central Nervous System (Rodents)
  • Functional observation battery
  • Locomotor activity
Cardiovascular System – Telemetry (Canines, Non-Human Primates)
  • Blood pressure
  • Body temperature
  • Electrocardiogram (QT/QTc)
  • Heart rate
Respiratory System (Canines, Non-Human Primates)
  • Tide volume
  • Respiratory rate
  • Minute volume