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Analytical Chemistry / Separations

Analytical Chemistry and Purification Sciences

The Pharmaron analytical chemistry team provides high quality analytical service (such as structural characterization, in-process control and release testing) to MedChem, Synthetic Chemistry and Process Chemistry departments The purification group within the analytical chemistry department specializes in chiral and achiral purifications (SFC, HPLC) on scales ranging from milligrams to hundreds of grams.

Instrumentation:

Numerous LC/MS (including UFLC/MS and UPLC/MS with PDA, ELSD and CAD detectors), LC/MS/MS, UPLC-QTOF, HPLC, GC/MS, GC and Headspace-GC/MS; KF, Automatic Titrator; NMR, UV, IR; ICP-OES/MS, IC; XRPD, DSC, TGA; Stability chambers; MS directed Prep-HPLC, Prep-HPLC, HP-Flash, DAC; Waters Autopurification Systems, SFC (Analytical and Preparative), UPC2, UPC2/QDa, Polarimeter.

We can provide analytical service as below:

  1. Method development and validation
  2. Characterization of compounds and reference standards
  3. Analysis of potential genotoxic impurities (PGIs)
  4. Isolation and structure elucidation of impurities or degradation products
  5. Stability study
  6. Large scale chiral separation or achiral purification (from g to kg)

Examples of Recent Projects:

  • Separated 430 g of product from a diastereoisomer impurity in one day
  • Completed 300g of racemate chiral separation of final product using SFC in one day.
  • Completed 5kg of racemate chiral separation of final product using SFC in 5 weeks.
  • Developed preparative separation method of a series of compounds with 4 diastereoisomers.
  • 2.5 kg of crude samples were purified on DAC in one day