• Pathology

Safety Pharmacology

Safety pharmacology studies are designed to investigate effects of test articles on vital functions in mammalian species. Primary evaluations include cardiovascular, respiratory, and central nervous system assessment. Supplemental evaluations of renal/urinary function, gastrointestinal function, and immune function may also be performed. The following types of safety pharmacology studies, in both large and small animal species, are conducted in compliance with GLP regulations, either stand-alone specifically or incorporated within toxicology studies.

Core Battery Tests 

  • Central Nervous System (Rodents, Canines, Minipigs and Non-Human Primates)
    • Functional observation battery (FOB – rodents, canines, minipigs and NHPs)
  •  Cardiovascular System
    • Radiotelemetry (Rats, Guinea Pigs, Canines, Non-Human Primates)
      • Blood pressure
      • Electrocardiogram (QT/QTc)
    •  Noninvasive cardiovascular assessments in conscious large animals
      • ECG: Multi-leads/Lead II ECGs
      • Blood pressure: Non-invasive
    •  In vitro cardiovascular evaluation
      • Multiple ion channels and cell cultures 
  • Respiratory System (Rodents, Canines, Non-Human Primates)
    • Tide volume
    • Respiratory rate
    • Minute volume