Accelerator Mass Spectrometry (AMS) Services

Pharmaron is the recognized leader in using Accelerator Mass Spectrometry (AMS) technology. Our team is primarily focused on pharmaceutical and biopharmaceutical R&D, employing Accelerator Mass Spectrometry (AMS) as a unique, alternative, ultra-sensitive ¹⁴C analytical tool to support both clinical and non-clinical metabolism programs. In addition to the typical AMS study designs below, Pharmaron can offer unique solutions to specific compound-related questions.

Advantages of using AMS technology include ultra-sensitive LLOQs (sub-pg equivalents per mL), no matrix interference and no sample carryover for the graphitization process.

Standard Clinical Designs:

• Mass balance and total [¹⁴C] by AMS (total radioactivity levels)
• Metabolite profiling by LC fractionation with detection by AMS
• Absolute bioavailability (IVPK) – IV ¹⁴C-microtracer by validated LC-AMS bioanalytical assay
• ¹⁴C dose solution analysis for low specific activity ¹⁴C dose preparations