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Imaging within Drug Discovery and Development

This webinar will focus on imaging techniques requiring radiolabeled material (QWBA/MARG) and some of those that do not (mass spectrometry).

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Agenda:

1. Overview of Imaging Techniques
   • The role of MS imaging in drug discovery
   • Combination of MS Imaging and Cell models
   • Case Study presented highlighting distribution & effects of Cetuximab in an aggregated model of osteosarcoma
2. Applications for Autoradiography within non-clinical ADME (Claire Henson)
   • The role of QWBA in drug development and non-clinical ADME
   • Using mARG to investigate tissue targeting at the cellular level
   • Combining QWBA & mARG to investigate targeted regional localisation
   • Application of Autoradiography within Receptor Binding studies

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Moderated by: Chunyan Han, Ph.D. - Senior Director, in vitro ADME, DMPK at Pharmaron 

Speakers:

Professor Malcolm Clench - Head of Research for the Biomolecular Sciences Research Centre at Sheffield Hallam University

Professor Malcolm Clench is Head of Research for the Biomolecular Sciences Research Centre, Dept. of Biosciences and Chemistry, Sheffield Hallam University in the United Kingdom. He is the leader of the Mass Spectrometry and MALDI Special Interest Group of the British Mass Spectrometry Society, Vice President of the Mass Spectrometry Imaging Society and Associate Editor of the Journals Proteomics and Nature Scientific Reports. Malcolm is the author of 136 peer reviewed papers to date including 75 on mass spectrometry imaging. He has supervised 34 PhD students to completion. Malcolm’s current major research interests are in the application of mass spectrometry imaging techniques to the understanding of response mechanisms to xenobiotic exposure in tissues and 3D tissue models and the development of quantitative imaging techniques.

Claire Henson - Senior Autoradiography Specialist at Pharmaron 

Claire has worked in Drug Metabolism for more than 25 years, beginning her career in the DMPK department at Huntingdon Life Sciences, where she developed a particular interest in tissue distribution using autoradiography imaging techniques. Having joined Biodynamics (now Pharmaron UK) in 2000, Claire now acts as a Senior Technical Specialist in autoradiography, involved in the management and improvement of whole-body autoradiography and micro-autoradiography studies. Claire has served on the management committees of both the ESA (European Society for Autoradiography) and the DMDG, and is currently Course Leader and tutor for the DMDG’s Tissue Distribution and Imaging training course.