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What is the impact of transporters in ADMET?

This webinar will show the importance and complexity of transporter-based drug interactions.

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  • Drug-drug interactions involving transporter inhibition: Recent experiences with cut-off criteria
    • Overview of transporter-based DDIs
    • Cut-off criteria for OATP1B1/BCRP/P-gp/OCT2/MATEs inhibition
    • General guidance for prospective predictions
  • How do we evaluate the interactions of drugs with transporters and what are some important factors to consider?
    • Test systems and considerations
    • Optimized experimental conditions to ensure clinically relevant outcomes
    • General principles and specific case studies

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Moderated by:  Barry Jones, Ph.D. - Senior Research Fellow, Metabolism at Pharmaron

Key Opinion Leader: Manthena Varma, PhD -  Research Fellow at Pfizer Inc

Dr. Varma received his B. Pharm. degree from the Kakatiya University, Warangal, India; and an M.S. degree and PhD in Pharmaceutics, from the National Institute of Pharmaceutical Education and research (NIPER), Mohali, India.  Later, Dr. Varma worked as a Post Doctoral Fellow at the Department of Pharmaceutics, University of Minnesota (Minneapolis). In 2008, he joined Worldwide R&D, Pfizer, Groton, CT.  Dr. Varma’s research is focused in the fields of ADME/PK technologies and strategies in drug design and development, role of drug transporters and transporter-enzyme interplay (extended clearance) in ADME/PK, clinical pharmacokinetics and DDI risk assessment via mechanistic (PBPK) modeling. Varma supported preclinical and clinical development of several Pfizer compounds in the oncology, metabolic diseases, and more recently in NASH/NAFLD therapeutic areas. Dr. Varma holds an Adjunct faculty position in the Department of Pharmacy of the University of Rhode Island. He published about 130 original articles/reviews and presented over 75 presentations at the scientific conferences.

Pharmaron Speaker: Qing Wang, PhD - Director of Drug Transporter Study at Absorption Systems, a Pharmaron company

Dr. Qing Wang obtained the Bachelor of Science degree in pharmaceutical science in Shenyang Pharmaceutical University in China, and the Doctor of Philosophy degree in pharmaceutical science in Rutgers University in New Jersey, USA.  Since 2002, Dr. Wang has been with Absorption Systems.  

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