Absorption, distribution, metabolism, and excretion of an antiviral drug-Fc conjugate CD388 following subcutaneous administration of 14C-CD388 in the rat
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Authors: Aline Laenen, Shawn Flanagan, Grayson Hough, Jan Snoeys, Filip Cuyckens, Geert Mannens, Stephen Harris, Voon Ong
Results indicated widespread tissue distribution and a plasma half-life of 210 hours. CD388 was the only circulating plasma species present with two metabolites containing unmodified dimeric Zanamivir present in urine.
Drug Metab Dispos. 2025 Jul;53(7):100103.
DOI: 10.1016/j.dmd.2025.100103
Access the publication at:https://pubmed.ncbi.nlm.nih.gov/40540979/