Evaluating Irrigating Solutions in a Corneal Wound Healing Model

Poster Authors:

Sudan Puri, Vivian Trenti, Yesica Chaparro, Sujata Rijal, Hannah Gill, Xiaohui Zhang, Stephanie Peters, James Lee, Sandeep Kumar, Glenwood Gum

Ophthalmology, Pharmaron US Lab Services, San Diego, CA, United States

Corneal injuries, especially alkali burns, can cause severe vision impairment, underscoring the need for optimized treatment strategies. This research focuses on developing effective eye injury treatments by evaluating various irrigating solutions in an ocular animal model. Corneal alkali burns were induced using New Zealand White rabbits with 1% NaOH. Post-injury, eyes were irrigated for 15 minutes with six different solutions. The healing progress was assessed via advanced imaging and slit lamp biomicroscopy. The findings revealed that sterile water was the least effective, while phosphate-buffered saline significantly reduced corneal edema, demonstrating its efficacy in corneal wound healing.

Download the poster to explore detailed findings from our corneal wound healing model.