Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. 

Graphic announcing a publication on discovering GluN2A‑selective NMDA receptor positive allosteric modulators and tuning deactivation kinetics, with a ‘View Publication’ button

Capabilities

Knowledge Center
Laboratory Chemistry
Connect with a Scientific Expert

Authors: Matthew Volgraf, Benjamin D. Sellers, Yu Jiang, Guosheng Wu, Cuong Q. Ly, Elisia Villemure, Richard M. Pastor, Po-wai Yuen, Aijun Lu, Xifeng Luo, Mingcui Liu, Shun Zhang, Liang Sun, Yuhong Fu, Patrick J. Lupardus, Heidi J. A. Wallweber, Bianca M. Liederer, Gauri Deshmukh, Emile Plise, Suzanne Tay, Paul Reynen, James Herrington, Amy Gustafson, Yichin Liu, Akim Dirksen, Matthias G. A. Dietz, Yanzhou Liu, Tzu-Ming Wang, Jesse E Hanson, David Hackos, Kimberly Scearce-Levie, Jacob B. Schwarz

J Med Chem. 2016 Mar 24;59(6):2760-79

DOI: 10.1021/acs.jmedchem.5b02010

Access the publication at:https://pubmed.ncbi.nlm.nih.gov/26919761/