High-throughput co-former screening and structural elucidation using resonant acoustic mixing and 3D electron diffraction

Authors: Jacob Danks ^ac, Daniel N. Rainer ^C, Ahmed S. Hamza ^a, Simon J. Coles ^b, Anthony B. Carter ^a, and Joseph E. G. Benson ^a

^aPharmaron, Hoddesdon, UK
^bSchool of Chemistry and Chemical Engineering, University of Southampton, UK
^cSchool of Chemistry, University of Lincoln, UK

High-Throughput Co-former Screening and Structural Elucidation

Pharmaron is delighted to share a recent collaborative publication in CrystEngComm, developed in partnership with the UK National Crystallography Service located at the University of Southampton, UK.

The Pharmaron Material Sciences team in Hoddesdon, UK conducted high-throughput resonant acoustic mixing (RAM) screening to identify novel multicomponent forms of sulfasalazine. This work was complemented by our collaborators in Southampton, who applied 3D electron diffraction to solve the resulting structures, leading to the interesting observation of tautomerism within a single crystal.

This integrated workflow is a step forward in solid-form screening and highlights our commitment to supporting impactful, industrial relevant science.

Pharmaron would also like to thank the University of Lincoln for supporting Jacob Danks during his Industrial Placement that enabled this work.

CrystEngComm, 2026, 28, 2018-2022.

DOI: 10.1039/D5CE01188D

Access the publication at: https://pubs.rsc.org/en/content/articlelanding/2026/ce/d5ce01188d