Virtual Lecture: Radical-Based Approach for Synthesis of Complex Natural Products

Lecture held on: November 23, 2022

Presenter

Prof. Masayuki Inoue – Laboratory of Synthetic Medicinal Chemistry, The University of Tokyo, Tokyo, Japan

Natural products with a high ratio of sp-hybridized atoms and oxygen-substituted stereogenic centers represent privileged structures for the development of pharmaceuticals and chemical probes. The multiple oxygen functionalities of these natural products endow their potent and selective biological activities, although they significantly heighten the challenge of their chemical assemblies. In this lecture, Prof. Masayuki Inoue focused on developing efficient strategies for the total syntheses of this biologically and chemically important class of molecules. Specifically, we designed and devised radical-based strategies for assembling highly oxygenated natural products. Prof. Masayuki Inoue reported the development of the radical coupling reactions and the synthetic routes to resiniferatoxin, hikizimycin, and euonymine by applying the radical chemistry.