Discovery of a potent (4R,5S)-4-fluoro-5-methylproline sulfonamide transient receptor potential ankyrin 1 antagonist and its methylene phosphate prodrug guided by molecular modeling

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Authors: Chen,H; Volgraf, M; Do, S; Kolesnikov, A; Shore, D; Verma, V; Villemure, E; Wang, L; Chen, Y; Hu, B; Lu, A; Wu, G; Xu, X; Yuen, P; Zhang, Y; Erickson, S; Dahl, M; Brotherton-Pleiss, C; Tay, S; Ly, J; Murray, L; Chen, J; Amm, D; Lange, W; Hackos, D; Reese, R; Shields, S; Lyssikatos, J; Safina, B; Estrada, A

J Med Chem. 2018 Apr 26;61(8):3641-3659

DOI: 10.1021/acs.jmedchem.8b00117

Access the publication at:https://pubmed.ncbi.nlm.nih.gov/29590749/