Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second Generation Analogs with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in vivo

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Authors: Burch, J; Barrett, K; Chen, Y; DeVoss, J; Eigenbrot, C; Goldsmith, R; Ismaili, M.H; Lau, K; Lin, Z; Ortwine, D; Zarrin, A; McEwan, P; Barker, J; Ellebrandt, C; Kordt, D; Stein, D; Wang, X, Chen, Y; Hu, B; Xu, X; Yuen, P; Zhang, Y, Pei, Z.

J Med Chem. 2015 May 14;58(9):3806-16

DOI: 10.1021/jm501998m

Access the publication at:https://pubmed.ncbi.nlm.nih.gov/25844760/