Virtual Lecture: Development of Novel C-H Functionalization Methodologies

Lecture held on: April 26, 2023

Presenter

Prof. Vladimir Gevorgyan – Department of Chemistry & Biochemistry, University of Texas at Dallas, TX, USA

We have developed a set of new transition metal catalyzed C-H functionalization methodologies employing various tether strategies. These methods feature: (a) use of silyl group as a tether between a substrate and a reagent, thus transforming intermolecular reaction into an intramolecular reaction; (b) employment of a silicon tethered directing group, which is traceless or easily convertible into valuable functionalities; (c) use of reactive silyl-tethered hydrosilane group; and (d) introduction of new N/Si-chelation concept that allows for a remote activation of aliphatic C H bonds. We uncovered new reactivity of hybrid Pd-radical species, generated at room temperature under visible light without use of exogenous photosensitizers. This led to the development of novel transformations, including new types of Heck reaction, aliphatic C-H functionalization methods, as well as new cascade transformations. A set of both directed and direct functionalization methods have been developed.