Virtual Lecture: Single Atom Logic for Skeletal Editing

Lecture held on: July 25

Presenter

Prof. Mark Levin – Department of Chemistry, The University of Chicago

Reactions which can manipulate the connectivity of the molecular skeleton are underexplored as tools for late-stage functionalization, in part because their implementation has been hindered by their often nonintuitive retrosynthetic logic. In this lecture, Prof. Mark Levin will cover selected transformations discovered in his laboratory which address this challenge, enabling single-atom changes through the insertion, deletion, and/or exchange of single heavy atoms (C, N, O, etc.). Prof. Mark Levin’s approach to this problem is modality-agnostic, drawing from a wide range of reactive species and synthetic disciplines, but with a significant focus on reagent design and photochemistry. Applications to the synthesis and diversification of complex pharmaceutically relevant compounds as well as unique opportunities for synthesis will be presented alongside mechanistic findings.