Discovery Biologics
The discovery biologics team provides services in custom recombinant antibody/protein production, antibody/protein engineering, stable gene expression cell line development, in addition to physical and biological characterization of proteins by SPR, LC-MS, TSA, etc. The team is experienced in recombinant protein expression and purification, protein analysis, playing active roles in small molecule compound screening as well as research and development of antibody-based therapeutics. The team is continuously expanding its service capabilities and capacities in biologics research and development.
- Gene expression and stable cell line development
- Recombinant protein engineering, expression, purification and characterization
- Recombinant protein/antibody production (bacterial, yeast, insect and mammalian cells)
- Protein characterization via SEC-HPLC, NanoDSF, capillary electrophoresis, etc.
- Support compound screening by SPR-, LC-MS-, and/or TSA-based techniques
Biologics Expression and Characterization
Pharmaron provides custom antibody and protein expression and subsequent physical and biological characterization services. Our team has a wide range of antibody, protein and peptide experience supporting drug discovery and development programs, from research-grade tool proteins, to first-in-class bi-specific therapeutic antibodies. Combined with our deep in vitro and in vivo biology experience, Pharmaron can be an integral partner at multiple stages of your biologics research and development programs.
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Process Development for GMP Manufacturing
Pharmaron’s process development services are comprised of a multidisciplinary team of experienced scientists who are focused on increasing efficiency, lowering costs and improving validation. We emphasize technology and method transfer, interrogation of biologics starting materials, lab-scale analytical evaluations and pilot-scale non-GMP manufacturing runs in preparation for GMP production. Our team is focused on ensuring research and development methods are seamlessly transferrable to GMP manufacturing processes.
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