in vivo PK

Pharmaron offers in vivo PK, toxicokinetics (TK) and formulation analysis services to support drug discovery and preclinical development for small molecules, peptides, nucleosides/nucleotides and biologics. All in-life work of PK/TK studies are conducted in AAALAC-accredited animal facilities and follow IACUC-approved study protocols.

• Formulation screening
• Cassette and single compound PK in mouse, rat, rabbit, mini pig, guinea pig, dog, monkey
• Tissue distribution
• Special dosing routes: infusion, intratracheal, intracolon, etc.
• Portal vein and bile duct cannulation
• Quantitative analysis of samples with various biological matrices
• Microdialysis for compound unbound concentration measurement
• Ussing chamber for evaluating intestinal permeability, metabolism and transporters interaction