Structural Biology Services

Pharmaron’s structural biology services provide the visualization of how your compound and target will interact, allowing for a more efficient and effective design-synthesis-testing cycle.

This capability is established through a robust process that includes quick plasmid generation, cell line generation, protein expression and purification followed by the complexing with small molecules to generate crystals of protein/small molecule complexes and their structure determination.

Capabilities

Structural Biology

in vitro Biology

DMPK

in vivo Pharmacology

Compound Management

Gene to Protein Structure Determination

Plasmid creation and cell line generation
Protein expression and protein purification for in vitro assay and crystallization
Protein crystallization of novel or published targets
Crystal structure determination and analysis of novel or published targets
Generation of small molecule complexes with protein through soaking and/or co-crystallization

Related Services

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Learn more about Pharmaron’s biosciences services

Pharmaron’s in vitro biology, in vivo pharmacology, DMPK and discovery biologics services support drug discovery and early development programs. Integration of these functions, together with laboratory chemistry, CMC and safety assessment, successfully deliver preclinical candidates and IND packages.

Learn more about Pharmaron’s integrated drug discovery and development services

Pharmaron provides a complete integrated platform from drug discovery to proof of concept (“POC”). Our industry knowledge, strong execution tactics and end-to-end solutions shorten the drug discovery and development cycle.