PD/PK

PD/PK studies help confirm the test article exposure and biomarker level in systemic circulation and tissues, particularly in target organs to understand the correlation of the test article exposure with its PD effect using diseased or healthy animal models. The quantification of the test article is conducted by the DMPK and in vitro biology teams.

  • Maximum tolerated dose
  • Dose range finding
  • Compound exposure in blood and tissue
  • Biomarkers in blood and tissue levels

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