Small Molecule Drug Disposition Studies

Combined with analytical techniques, such as quantitative LC-MS/MS, HR-MS, HPLC, UPLC, LSC and AMS (accelerator mass spectrometry), our team provides comprehensive services for investigating the metabolism/PK of candidate drugs in clinical development.

• LC-MS/MS bioanalysis for parent compound
• HR-MS analysis for metabolites
• LSC and AMS analysis for total radioactivity
• LC/LSC and LC+AMS bioanalysis for ¹⁴C parent compound and ¹⁴C metabolites
• Metabolite profiling by LC, LSC, AMS and HR-MS
• Drug-drug interactions
• Biomatrix: Blood, plasma, feces, urine

Clinical study designs include:

• Mass balance and metabolism (human ADME)
• PK with absolute bioavailability
• High-dose (50 to 100 µCi) ¹⁴C radiolabelled studies
• Low-dose (<1 µCi) ¹⁴C microtracer studies