Medicinal Chemistry

The medicinal chemistry teams support our partners’ needs for hit identification (HI), lead generation (LG) and lead optimization (LO) programs.

  • Scaffold design for hit identification
  • Preliminary intellectual property (IP) analysis on newly designed scaffolds
  • Synthesis of focused libraries for LG and LO
  • SAR analysis based on in vitro and in vivo data
  • Computer-aided drug design and diversity analysis
  • Non-GMP scale-up to support in vivo efficacy and toxicity studies
  • Patent application preparation
  • Recommendation of appropriate DMPK and in vitro toxicology studies to help key compound advancement
  • Project management

Our partners have the opportunity to work directly with our medicinal chemistry and CADD teams either in China or in the UK, or a flexible combination of these resources via our unique operating model.

Computer-aided Drug Design Publications

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