Medicinal Chemistry

The medicinal chemistry teams support our partners’ needs for hit identification (HI), lead generation (LG) and lead optimization (LO) programs.

• Scaffold design for hit identification
• Preliminary intellectual property (IP) analysis on newly designed scaffolds
• Synthesis of focused libraries for LG and LO
• SAR analysis based on in vitro and in vivo data
• Computer-aided drug design and diversity analysis
• Non-GMP scale-up to support in vivo efficacy and toxicity studies
• Patent application preparation
• Recommendation of appropriate DMPK and in vitro toxicology studies to help key compound advancement
• Project management

Our partners have the opportunity to work directly with our medicinal chemistry and CADD teams either in China or in the UK, or a flexible combination of these resources via our unique operating model.

Computer-aided Drug Design Publications