High-Throughput Screening
High-Throughput Screening Service
Pharmaron supports drug discovery with state-of-the-art solutions for high-throughput screening services. Our fully automated G3 Explorer high-throughput screening system from Revvity operates with two robotic arms in an enclosed suite with a turnover of about 200 plates per day, amounting to up to 150,000 compounds per week, depending on the assay readout. Plate formats include 96, 384, and 1,536 wells.
The high throughput screening service options include semi- and fully automated workflows to perform biochemical, binding, and cell-based assays with a wide range of readouts ranging, from simple fluorescence to complex high-content imaging.
Clients value the high quality of data generated by the high throughput screening assays, particularly the high reproducibility of our data.
We provide in-house protein production and cell line engineering, enabling swift development of new assays for high throughput screening campaigns.
No waiting time for study initiation, full transparency, state-of-the-art compound management, and high-quality data, along with our highly effective project management system, can accelerate the launch and completion of high-throughput screening campaigns to support our clients’ drug discovery endeavors.
Download our brochure about Pharmaron’s fully automated HTS screening platform
Capabilities
High-Throughput Screening Readouts
- Enzyme activity
- Binding affinity
- Target engagement
- Protein-protein interaction
- Phenotypic readouts in 2D and 3D cellular assays
- High-content imaging
- Reporter signal
- RNA expression
- Biomarkers
Assay Platforms Available for High-Throughput Screening Service
- Affinity-selection mass spectrometry
- Fluorescence intensity
- Fluorescence polarization
- HTRF
- AlphaLISA, ELISA, MSD
- Luminescence
- Microscopic imaging
- qPCR
- NanoBRET
- HiBiT
- Electrophysiology
- Second messengers, Ca2+
Library Options
- Customer library
- Third-party library
- Pharmaron libraries
- Hand-selected diversity compound library
- Fragment library
- Kinase inhibitor library
Key Instrumentation for HTS Screening
- Explorer G3 integrated lab automation suite
- Operetta high-content imaging system
- Orbitrap Astral
- Envision
- SynchroPatch 384
- QuantStudio 5 and 7
- FLIPR
- MesoScale Discovery MSD
Modalities
- Small molecule compounds
- Small molecule fragments
- Covalent compounds
- Protein degraders
- Peptides
- Oligonucleotides
- Large molecules