¹⁴C Radiolabels and AMS for Biologics

Our team offers radiolabelling of biologics with ¹⁴C combined with Accelerator Mass Spectrometry (AMS) analysis to provide pharmacokinetic (PK) and tissue disposition data in animal models. Non-clinical Studies

• Analysis of parent compound in a wide range biological matrices (i.e. plasma, skin, kidney, liver, spleen, bile, excreta)
• Analysis of total ¹⁴C in all tissues/cells/biological fluids and expired air
• Radiolabelled cytokine/protein target turn-over studies
• Analysis of radiolabelled biologics in toxicology species
• Oligonucleotides, ADCs, therapeutic proteins, peptides, fusion proteins

Disposition of Radiolabelled Biologics
³H and ¹⁴C Radiolabels (RadioTag)