Carbon 14 (14C) Radiosynthesis

Our radiosynthesis team prepares and releases radiolabelled test compounds for use in non-clinical studies, clinical drug development and environmental fate studies. We provide expert advice on custom radiosynthesis design and optimal position for the radiolabel in the molecule.  

Unparalleled capabilities in custom 14C radiosyntheses including complex molecules, with particular experience as follows:

  • Volatile compounds, aromatics, heterocyclics, chiral compounds, peptides (peptide synthesis via solution chemistry/synthesizer), proteins (including fermentations), oligonucleotides, conjugates, polymers
  • Biomolecules using fermentation (Class 2 containment and Class 1 GMOs)
  • Covalent radiolabelling techniques with 14C (RadioTag) for macromolecules

GLP-compliant analytical chemistry support includes:

  • Mass spectrometry, HPLC (radioactivity detection and characterization of polymers), NMR, GC, FT-IR, DSC, TGA, KF
  • Audited external partners for ICP-MS, bio-burden

GMP Preparation of 14C Radiolabelled API & Drug Product

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