Tritium (3H) Radiosynthesis

Our team provides advice on radiosynthesis design and optimal position of the tritium (3H) label(s).

Dedicated tritium radiochemistry team provides custom tritium (3H) radiosyntheses with following techniques:

  • Tritium gas exchange using a hydrogen transfer catalyst
  • Tritiated water exchange
  • Catalytic reduction with Tritium gas
  • Reduction with [3H]Borohydride
  • Catalytic dehalogenation with Tritium gas
  • Catalytic Photoredox tritiation
  • High specific activity methylation using [methyl-3H]nosylate
  • Covalent labelling of macromolecules using [3H]NSP

Special Tritium Synthesis

  • Oligonucleotides
  • Peptides
  • Antibody-drug conjugates

Comprehensive analytical capabilities including GLP analysis:

  • Mass spectrometry
  • HPLC (radioactivity detection and characterization of polymers)
  • NMR (3H-NMR for identity and position of 3H label)
  • Gas Chromatography (GC)
  • FT-IR
  • DSC
  • TGA
  • KF

 

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