Genetic Toxicology

Pharmaron’s Genetic Toxicology team provides genotoxicity screening assays for discovery programs and standard GLP genotoxicity assays in support of regulatory guidelines and GLP standards.
 
Genotoxicity Screening Assays

• Mini Ames/Ames
• in vitro micronucleus: CHO cell, human lymphocyte
• Chromosome aberration: CHO cell, human lymphocyte
• Gene mutation: mouse lymphoma
• in vivo rodent bone marrow micronucleus

GLP Standard Genotoxicity Assays

• Ames
• in vitro micronucleus: CHO cell, human lymphocyte
• Chromosome aberration: CHO cell, human lymphocyte
• Gene mutation: mouse lymphoma
• in vivo rodent bone marrow micronucleus, independent or integrated into general toxicology studies in rodent