Virtual Lecture Series:
Frontiers in Synthetic and Medicinal Chemistry

On-demand Lecture Now Available (Recorded on Thursday, August 31)

Pharmaron’s Virtual Lecture Series launched in July 2020 to provide our team and partners with online educational opportunities. Each month a world-class scientist from a renowned academic institution presents novel research related to organic chemistry. This series has contributed to cultivating a vibrant learning culture at Pharmaron and continues to be a key source to gain knowledge about the most advanced developments in organic chemistry.

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Applied Late-stage Functionalization: Where Chemistry Meets Biology (C–H Activation for Late-Stage Diversification of Biomolecules)
Prof. Lutz Ackermann, 
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Göttingen, Germany

The continuously increasing demand for complex molecular scaffolds in biology and material sciences, as well as agrochemical and pharmaceutical industries translates into a continued strong demand for innovative molecular syntheses. Non-natural peptides have emerged as increasingly potent scaffolds in medicinal chemistry and the pharmaceutical industry. As a consequence, the chemoselective assembly and modification of structurally complex peptides continues to be of utmost importance. Significant recent momentum was gained through the development of palladium-catalyzed cross-couplings of peptides. A significantly more atom- and step-economic strategy relies on the direct activation of otherwise unreactive C–H bonds,1 with recent transformative applications towards peptide modification.2 As part of our program on sustainable C–H activation, we have unraveled new methodologies that allow the expedient functionalization of not only peptides,3 but also carboranes,4 saccharides,5 and complex drug molecules6 based on sustainable C–H activation.

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