Accelerator mass spectrometry video presentation by Adrian Pereira, Principal Scientist at Pharmaron, covering AMS problems and solutions

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Introduction to Accelerator Mass Spectrometry (AMS)

Accelerator Mass Spectrometry (AMS) is an ultra-sensitive technique used in hAME and IVPK clinical sample analysis. AMS has transformed the way we study drug metabolism and pharmacokinetics. The sensitivity of AMS enables the detection and quantification of low-level metabolites for drugs and complex metabolism profiles. In this presentation, Adrian Pereira explores how AMS solved critical challenges in drug development, the evolution of the technology, and what the future holds.

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What you will learn in this presentation:

What is AMS?
- Understand the fundamental science behind AMS technology and how it measures carbon isotopes at the atomic level.
Why AMS Matters.
- Discover what makes AMS is 500x more sensitive than traditional decay counting and up to 100x more sensitive than LC-MS, enabling ultra-low-dose studies in humans.
Learn how AMS supports drug development activities:
- Human ADME (hADME) studies.
- Absolute bioavailability studies.
- Microdose studies.
- Safer, faster clinical trials aligned with 3R principles.
Case Studies.
- Adrian presents a number of case studies, including:
  - An ADME study for a drug with a long elimination half-life.
  - A topical drug study with minimal systemic exposure.
Challenges and Solutions in AMS.
- Explore hurdles in instrumentation, sample preparation, throughput, and metabolite profiling, and how innovation has overcome these issues.
What the Future of AMS Looks Like:
- Smaller, more robust instruments, automated workflows, and integration with advanced analytical tools like NMR.

Ultimately, AMS is no longer confined to academic labs and has a variety of uses and applications across the pharma and biotech fields. Whether you are a researcher, biotech entrepreneur, or CRO scientist, user-friendly instruments and improved software ensure that AMS is now more accessible worldwide.

Meet our Presenter

Adrian Pereira, Principal Scientist

Adrian Pereira, Principal Scientist at Pharmaron

Adrian Pereira is a Principal Scientist working in the AMS and
Biotransformation Group at Pharmaron UK, with over 20 year’s experience
in the pharmaceutical industry. He has a passion for AMS technology and
its transformative applications to drug development and has been working
in this field for about 9 years. His main work experience comes from his
time at GSK where he held pivotal roles across various departments,
including Bioanalysis, Biotransformation, AMS and study outsourcing
groups. He has spent the last 18 months at Pharmaron helping with the
designing, setting up and installation of a state-of-the-art AMS laboratory
at the Hoddesdon UK site. He holds an MSc in Biopharmacy from King’s
College, London and a BSc in Applied Chemistry from Aston University,
Birmingham.

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