Accelerator Mass Spectrometry: Problems Solved and Challenges to Overcome

Introduction to Accelerator Mass Spectrometry (AMS)

Accelerator Mass Spectrometry (AMS) is an ultra-sensitive technique used in hAME and IVPK clinical sample analysis. AMS has transformed the way we study drug metabolism and pharmacokinetics. The sensitivity of AMS enables the detection and quantification of low-level metabolites for drugs and complex metabolism profiles.  In this presentation, Adrian Pereira explores how AMS solved critical challenges in drug development, the evolution of the technology, and what the future holds.

What you will learn in this presentation:

• What is AMS?
  • Understand the fundamental science behind AMS technology and how it measures carbon isotopes at the atomic level.
• Why AMS Matters.
  • Discover what makes AMS is 500x more sensitive than traditional decay counting and up to 100x more sensitive than LC-MS, enabling ultra-low-dose studies in humans.
• Learn how AMS supports drug development activities:
  • Human ADME (hADME) studies.
  • Absolute bioavailability studies.
  • Microdose studies.
  • Safer, faster clinical trials aligned with 3R principles.
• Case Studies.
  • Adrian presents a number of case studies, including:
    • An ADME study for a drug with a long elimination half-life.
    • A topical drug study with minimal systemic exposure.
• Challenges and Solutions in AMS.
  • Explore hurdles in instrumentation, sample preparation, throughput, and metabolite profiling, and how innovation has overcome these issues.
• What the Future of AMS Looks Like:
  • Smaller, more robust instruments, automated workflows, and integration with advanced analytical tools like NMR.

Ultimately, AMS is no longer confined to academic labs and has a variety of uses and applications across the pharma and biotech fields. Whether you are a researcher, biotech entrepreneur, or CRO scientist, user-friendly instruments and improved software ensure that AMS is now more accessible worldwide.

Meet our Presenter