Target Identification and Validation Services

Pharmaron employs a multifaceted approach based on state-of-the-art technologies to identify promising new targets.

Target identification at Pharmaron is supported via three approaches:

• Gene or RNA editing facilitates the introduction of targeted mutations or knockdowns across numerous genes, allowing researchers to observe the effects on cellular processes.
• Through next-generation sequencing (NGS) and gene expression profiling, Pharmaron’s scientists can identify mutations and gene expression patterns linked to pathological conditions.
• Phenotypic drug discovery is performed via a cell painting approach to detect changes in the phenotypes of cells, identifying disease drivers.

Our team of seasoned professionals ensures that each identified therapeutic target is scientifically validated. Our outstanding capability in cell line engineering is at the heart of our target validation approach. A myriad of phenotypic assays are available at Pharmaron to study the effects of target manipulation on cells.

Furthermore, our in-house genomics and proteomics capabilities comprehensively understand how the target interplays with disease phenotypes. Our bioinformatics team conducts in-depth pathway and biological function analyses, offering a holistic view of the target’s role in disease.