Tritium Radiosynthesis

A person wearing safety glasses, a lab coat, a purple glove, and a blue sleeve cover operates equipment in a laboratory fume hood. The fume hood has gauges, knobs, and a glass door. The surrounding lab appears clean and sanitized as they conduct genetic toxicology experiments.

Tritium Radiosynthesis Services

Pharmaron’s team of tritium experts work together with you to develop a radiolabelling strategy for the compound(s) and desired applications including late-stage lead optimization of candidate compounds. Our team provides advice on custom tritium-labelled compounds and optimal position(s) of the tritium [3H] label(s).

Tritium Radiosynthesis Techniques

  • Tritium gas exchange using modern heterogenous and homogeneous catalysts
  • Tritiated water exchange
  • Catalytic reduction with tritium gas
  • Reduction with [3H]Borohydride
  • Catalytic dehalogenation with tritium gas
  • Catalytic photoredox tritiation
  • High specific activity methylation using [methyl-3H]nosylate
  • Covalent tritium labelling of macromolecules using [3H]NSP
Pharmaron Lab Chemist

Specialized Tritium Labelling

  • Nucleotides, oligonucleotides
  • Peptides
  • Proteins
  • Antibodies, antibody-drug conjugates (ADCs)
  • Carbohydrates

0

Pharmaron Chemist in Lab

Analytical Chemistry Support for Tritiated Compounds

  • Mass spectrometry (LC-MS/MS)
  • HPLC or UPLC (with UV and flow-through radio-detectors)
  • NMR (3H-NMR for identity, structural confirmation and position of 3H label)
  • Gas chromatography (GC)
  • FT-IR, DSC, TGA, KF
  • GLP compliance or GLP analysis (if required)