Tritium Radiosynthesis
Tritium Radiosynthesis Services
Pharmaron’s team of tritium experts work together with you to develop a radiolabelling strategy for the compound(s) and desired applications including late-stage lead optimization of candidate compounds. Our team provides advice on custom tritium-labelled compounds and optimal position(s) of the tritium [3H] label(s).
Tritium Radiosynthesis Techniques
- Tritium gas exchange using modern heterogenous and homogeneous catalysts
- Tritiated water exchange
- Catalytic reduction with tritium gas
- Reduction with [3H]Borohydride
- Catalytic dehalogenation with tritium gas
- Catalytic photoredox tritiation
- High specific activity methylation using [methyl-3H]nosylate
- Covalent tritium labelling of macromolecules using [3H]NSP
Capabilities
Specialized Tritium Labelling
- Nucleotides, oligonucleotides
- Peptides
- Proteins
- Antibodies, antibody-drug conjugates (ADCs)
- Carbohydrates
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Analytical Chemistry Support for Tritiated Compounds
- Mass spectrometry (LC-MS/MS)
- HPLC or UPLC (with UV and flow-through radio-detectors)
- NMR (3H-NMR for identity, structural confirmation and position of 3H label)
- Gas chromatography (GC)
- FT-IR, DSC, TGA, KF
- GLP compliance or GLP analysis (if required)
