Oncology Animal Models

Oncology Animal Model Services

Our in vivo pharmacology team is experienced with oncology disease model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies.

The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services.

Study Types:

  • Development and validation of disease models
  • Maximum tolerated dose studies
  • Dose range finding studies
  • Efficacy screening studies

Oncology Disease Models

  • Large cancer cell line and tissue bank
  • CDX models and PDX models
  • Syngeneic models with completed immune profile and SOC data
  • Orthotopic imaging models (including intracranial models) using hundreds of human and murine cancer cell lines
  • A platform to support radiation therapy
  • Drug-specific resistance models
  • Genetically engineered tumor cell lines and corresponding mouse models

Analytical Platforms

  • Drug exposure in blood and tissue
  • Specific biomarkers in blood and tissue
  • Gene or protein analysis platforms
  • FACS analysis of cells, blood and tissue samples
  • Histology, biochemistry, IHC
  • Blood sample analysis with biochemistry and hematology
  • Analysis of body fluid, urine and feces