Oncology Animal Models

Oncology Animal Model Services

Our in vivo pharmacology team is experienced with oncology animal model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies.

The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services.

Learn more: Oncology and Immuno-oncology in vivo Pharmacology Solutions

Study Types:

  • Development and validation of disease models
  • Maximum tolerated dose studies
  • Dose range finding studies
  • Efficacy screening studies

Oncology Disease Models

  • Large cancer cell line (2,000+) and tissue bank
  • 1,000+ fully validated cell-line derived xenograft (CDX) models
  • 85+ syngeneic tumor models with complete immune profile and SOC data
  • 350+ patient-derived xenograft (PXD) models with patient history
  • 160+ orthotopic models of more than 15 cancer types including intracranial implantation

Analytical Platforms

  • Drug exposure in blood and tissue
  • Specific biomarkers in blood and tissue
  • Gene or protein analysis platforms
  • FACS analysis of cells, blood and tissue samples
  • Histology, biochemistry, IHC
  • Blood sample analysis with biochemistry and hematology
  • Analysis of body fluid, urine and feces

Learn more about Pharmaron’s Oncology and Immuno-Oncology Capabilities