Oncology Animal Model Services

Our in vivo pharmacology team is experienced with oncology animal model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies.

The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services.

Learn more: Oncology and Immuno-oncology in vivo Pharmacology Solutions

Study Types:

Development and validation of disease models
Maximum tolerated dose studies
Dose range finding studies
Efficacy screening studies

Capabilities

Oncology Animal Models

Cardiovascular and Metabolic Diseases Animal Models

Inflammation and Pain Animal Models

CNS/PNS Diseases Animal Models

Dermal Animal Models

Ophthalmology Animal Models

Medical Devices Animal Models

A large white X-ray machine labeled "X-RAD 225" with a warning sign and a door displaying "X-RAY ON." A digital control panel with buttons and labels is on the front. The machine, used in genetic toxicology studies, is situated in a clean, industrial environment.

Oncology Disease Models

Large cancer cell line (2,000+) and tissue bank
1,000+ fully validated cell-line derived xenograft (CDX) models
85+ syngeneic tumor models with complete immune profile and SOC data
350+ patient-derived xenograft (PXD) models with patient history
160+ orthotopic models of more than 15 cancer types including intracranial implantation

Analytical Platforms

Drug exposure in blood and tissue
Specific biomarkers in blood and tissue
Gene or protein analysis platforms
FACS analysis of cells, blood and tissue samples
Histology, biochemistry, IHC
Blood sample analysis with biochemistry and hematology
Analysis of body fluid, urine and feces

Learn more about Pharmaron’s Oncology and Immuno-Oncology Capabilities

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Image of a Pharmaron brochure. On the left, it reads, "Pharmaron’s Comprehensive in vivo Pharmacology Solutions," highlighting sections on "Oncology and Immuno-Oncology." On the right, it states "in vivo Oncology," alongside a button labeled "Download Service Overview." Plus, explore our Radiolabelled ADME services.

Related Services

Learn more about Pharmaron’s ex vivo Pharmacology & Biomarkers Services

The purpose of ex vivo analysis is to confirm the in vivo effect of test articles and to find out the correlation between in vivo efficacy and biomarkers. Our ex vivo team has years of experience and can support your drug discovery program by providing ex vivo pharmacology & biomarker analysis services.

Learn more about Pharmaron’s integrated drug discovery and development services

Pharmaron provides a complete integrated platform from drug discovery to proof of concept (“POC”). Our industry knowledge, strong execution tactics and end-to-end solutions shorten the drug discovery and development cycle.