Oncology Animal Models
Oncology Animal Model Services
Our in vivo pharmacology team is experienced with oncology disease model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies.
The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services.
Study Types:
- Development and validation of disease models
- Maximum tolerated dose studies
- Dose range finding studies
- Efficacy screening studies
Capabilities
Oncology Disease Models
- Large cancer cell line and tissue bank
- CDX models and PDX models
- Syngeneic models with completed immune profile and SOC data
- Orthotopic imaging models (including intracranial models) using hundreds of human and murine cancer cell lines
- A platform to support radiation therapy
- Drug-specific resistance models
- Genetically engineered tumor cell lines and corresponding mouse models
Analytical Platforms
- Drug exposure in blood and tissue
- Specific biomarkers in blood and tissue
- Gene or protein analysis platforms
- FACS analysis of cells, blood and tissue samples
- Histology, biochemistry, IHC
- Blood sample analysis with biochemistry and hematology
- Analysis of body fluid, urine and feces
