Developmental and Reproductive Toxicology

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Developmental and Reproductive Toxicology (DART) Services

Pharmaron provides developmental and reproductive toxicology (DART) services to evaluate agents for the life sciences industry. The DART team offers a comprehensive set of studies to evaluate developmental and reproductive toxic potential. They also offer customized study designs, such as ePPND.

DART Study Designs:

  • Fertility and early embryonic development
  • Embryo-fetal development
  • Perinatal and postnatal development
  • Prenatal developmental toxicity
  • One-Generation reproduction toxicity
  • Two-Generation reproduction toxicity
  • Reproduction/developmental toxicity screen
  • Extended one-generation reproductive toxicity
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Segment I Study Designs

  • Maturation of gametes
  • Mating behavior
  • Fertility
  • Pre- and post-implantation development
  • Sperm analysis

Segment II Study Designs

  • Maternal toxicity
  • Embryotoxicity
  • Fetotoxicity
  • Teratogenicity (fetal external evaluation, fetal soft tissue evaluation, fetal skeletal evaluation)
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Segment III Study Designs

  • Development landmarks
  • Sensory functions 
  • Motor activity
  • Learning and memory
  • Reproductive function