AMS for Carbon-14 Non-clinical Studies Services

The utilization of Accelerator Mass Spectrometry (AMS) in non-clinical studies is less common as high doses of ¹⁴C radioactivity in animal models are generally not restricted by radiological safety concerns. AMS-enabled non-clinical applications typically focus on potent compounds where doses in animal models are correspondingly low, requiring the ultra-sensitivity for ¹⁴C analysis that AMS provides.  By partnering with Pharmaron, we employ state-of-the-art AMS to generate the quantitative and qualitative data that helps to advance your development programs. 

AMS facilitates accurate quantitation of total [¹⁴C] and ¹⁴C-parent/metabolite(s) in a wide range of sample types (blood, plasma, excreta, tissues, cells, biological fluids). The sensitivity of AMS analysis only requires very small (mg/µg) sample sizes. We also employ AMS in conjunction with HPLC/UPLC fractionation methods for metabolite profiling in all biological matrices.

Radioanalysis can be integrated with Pharmaron’s radiosynthesis capabilities for radiolabelling both small and large molecules with ¹⁴C.