Tritium and Carbon-14 Radiolabels (RadioTag)

Woman wearing a mask working in the lab

Tritium and Carbon-14 Radiolabels (RadioTag) Services

Pharmaron’s radiochemistry team provides expert advice on synthesis of radiolabels and subsequent release for use in non-clinical and clinical drug development and in environmental fate studies. To support rapid turnaround PK investigations, we developed RadioTag, a technique pioneered by Pharmaron for radiolabelling large protein-based molecules with 3H or14C.   Pharmaron’s method for radiolabelling biologics can support pharmacokinetic, mass balance, tissue distribution (quantitative whole-body autoradiography (QWBA) and micro-autoradiography (mARG)) and metabolism studies. By using radio-tagging techniques, our team is able to rapidly assess the PK and tissue distribution of radiolabelled biologics. 

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RadioTag Method

  • Single protocol for a wide range of large molecules using a covalent radiolabelling technique
  • Direct labelling targets lysine residues or N-terminal amino groups in proteins and peptides
  • Wide molecular weight ranges studied from 1 to >350 kDa
  • Minimal protein modification reduces the potential negative effects on target binding or biological activity