Tritium and Carbon-14 Radiolabels (RadioTag)
Tritium and Carbon-14 Radiolabels (RadioTag) Services
Pharmaron’s radiochemistry team provides expert advice on synthesis of radiolabels and subsequent release for use in non-clinical and clinical drug development and in environmental fate studies. To support rapid turnaround PK investigations, we developed RadioTag, a technique pioneered by Pharmaron for radiolabelling large protein-based molecules with 3H or14C. Pharmaron’s method for radiolabelling biologics can support pharmacokinetic, mass balance, tissue distribution (quantitative whole-body autoradiography (QWBA) and micro-autoradiography (mARG)) and metabolism studies. By using radio-tagging techniques, our team is able to rapidly assess the PK and tissue distribution of radiolabelled biologics.
Capabilities
RadioTag Method
- Single protocol for a wide range of large molecules using a covalent radiolabelling technique
- Direct labelling targets lysine residues or N-terminal amino groups in proteins and peptides
- Wide molecular weight ranges studied from 1 to >350 kDa
- Minimal protein modification reduces the potential negative effects on target binding or biological activity
