Animal Disease Models

Animal Disease Model Services

Our in vivo pharmacology team is experienced with disease model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies. The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services in various therapeutic areas.

Models include oncology, cardiovascular and metabolic diseases, CNS/PNS diseases, inflammation and pain, ophthalmology, dermal diseases and medical devices.

Additional models available include hemostasis, leukocytopenia, intestine mobility, anemia, wounding/healing, renal failure, psoriasis and more.

Cardiovascular and Metabolic Models

  • Obesity
  • Type 1 diabetes
  • Type 2 diabetes
  • Cardiovascular diseases 
  • Organ damage diseases
  • Respiratory disease 
  • Hyperuricemia

CNS/PNS Models

  • Alzheimer’s disease
  • Memory impairment
  • Seizure
  • Parkinson’s disease
  • Depression / Anxiety / Schizophrenia 
  • Other neurodegenerative diseases

Dermal Disease Models

  • in vitro dermal models
  • ex vivo dermal models
  • in vivo dermal models

Inflammation and Pain Models

  • Acute and chronic pain models
  • Immune disease models
  • Non-immune inflammatory models
  • Arthritis
  • Visceral pain
  • Surgery pain
  • Neuropathic pain
  • PDPK models
Medical Device - Therapeutic Device

Medical Devices

  • Cardiovascular Device Testing
  • Ocular Device Testing
  • Metabolic Disease Device Testing

Oncology Models

  • Large cancer cell line and tissue bank
  • CDX models and PDX models
  • Syngeneic models with completed immune profile and SOC data
  • Orthotopic imaging models (including intracranial models) using hundreds of human and murine cancer cell lines
  • A platform to support radiation therapy

Ocular Disease Models

  • Glaucoma
  • Choroidal Neovascularization (CNV)
  • Age-Related Macular Degeneration (AMD)
  • Keratoconjunctivitis Sicca (KCS)
  • Allergic conjunctivitis
  • Anterior uveitis
  • Infectious keratitis
  • Neuroprotection
  • Corneal wound healing
  • Diabetic macular edema