Discovery Process Chemistry
Discovery Process Chemistry Services
Scaling your drug program from discovery to development is challenging. By bridging our discovery and process R&D capabilities, our dedicated discovery process chemistry team enables the rapid development of candidate compounds to accelerate programs to key preclinical milestones.
Pharmaron’s discovery process chemists support a wide range of services from late-stage lead optimization to candidate selection through preclinical development. We have a solid proven track record in providing advanced intermediates and active pharmaceutical ingredients (APIs) from gram scale preparation up to kilograms.
- Quickly obtaining intermediates to support medicinal chemistry programs
- Scale-up to support in vivo efficacy and toxicity studies
- Early process development to support clinical studies
Learn more: Enabling Technology
Capabilities
Route Design/Redesign
- Design of new routes for targets of any complexity
- Applications of the latest synthetic technologies
Optimization of Current Synthetic Routes
- Reaction screening
- Statistical approaches – design of experiments
- Intermediate stability and solubility studies
Compound Purification and Isolation Improvements
- Development of robust isolations
- Physical form monitoring
- Classical resolutions
- Impurity isolation and identification
Process Safety Evaluation
- Generation and interpretation of data to ensure safe scale-up
- Suite of techniques used to provide robust data
- Variety of equipment to evaluate the hazard of thermal stability, dust, static electricity and flammability
- RC-1, ARRST, DSC and power compensation calorimetry
Full Technical Transfer Documentation Provided
- Take your project to large scales
- Seamless tech transfer to other Pharmaron divisions
