A scientist in protective gear operates lab equipment through a touchscreen, performing pharmacokinetics/pharmacodynamics (PK/PD) analysis in a controlled environment.

PK/PD Services

PK/PD studies help confirm the test article exposure and biomarker level in systemic circulation and tissues, particularly in target organs to understand the correlation of the test article exposure with its PD effect using diseased or healthy animal models. Pharmaron’s experienced team provides PK/PD services to examine several parameters in support of regulatory submissions. The quantification of the test article is conducted by the DMPK and in vitro biology teams. Toxicokinetic studies can be conducted alongside ongoing toxicology programs as well.

A scientist operates the touchscreen of a QuantStudio 7 Flex system, performing PK/PD analysis for pharmacokinetics and pharmacodynamics research.

General PK/PD Evaluation

  • Formulation development
  • Bioavailability
  • Clearance
  • Half-life
  • Dose linearity study
  • Tissue distribution
  • Metabolite analysis
  • Biliary excretion
A scientist wearing gloves and a mask uses a pipette to prepare samples for pharmacokinetic/pharmacodynamic (PK/PD) analysis in a lab setting.

CNS PK/PD

  • CSF, Brain homogenate, Kp
  • Unbound level in brain, Kpuu
  • Microdialysis
Close-up of a SCIEX Triple Quad 5500 mass spectrometer used for pharmacokinetic/pharmacodynamic (PK/PD) analysis in a laboratory setting.

Absorption

  • Ussing Chamber, Fa/Fg/Fh evaluation
  • Intraduodenal/Intracolonic/Capsule dosing
A gloved scientist uses a pipette to fill small vials organized in an orange rack, conducting ADME profiling in a laboratory.

Drug-Drug Interactions (DDI)

  • Pre-treatment with CYP inhibitor
  • Transporters
    • P-gp
    • BCRP
    • OATP inhibitors/transgenic animal