Dermal Animal Models
Dermal Animal Model Services
Pharmaron’s team is able to incorporate in vitro, ex vivo, and in vivo non-clinical models to evaluate dermal delivery (tissue-based and pharmacokinetic models), compare and optimize formulations, minimize DoE runs, and guide critical investment decisions. We have access to board-certified pathologists and onsite support from attending veterinarians to ensure the study conduct in compliance and in accordance with animal welfare.
Pharmaron’s unique portfolio of dermal animal models provides a comprehensive package of predictive testing. We employ a rational and multi-pronged approach that relies on well-validated, nonclinical models to bypass clinical studies and/or enhance quality by design (QbD). This approach allows you to advance your dermatological innovations with increased accuracy and confidence.
Capabilities
in vitro Dermal Models
- in vitro release testing
- Topical formulation
- Stability
ex vivo Dermal Models
- in vitro permeation testing
- ex vivo dermal permeability
- Dermal permeability
- Penetration and accumulation
- Barrier integrity measurements
in vivo Dermal Models
- Dermal PK & irritation
- Dermal irritation study
- Dermal efficacy
- Wound healing