CNS/PNS Diseases Animal Models

CNS/PNS Diseases Animal Model Services

Our in vivo pharmacology team is experienced with CNS/PNS disease model establishment and validation for efficacy screening, in vivo pharmacology profiling, PDPK and MOA studies. The team is supported by internal PK/Bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services.

Study Types

  • Development and validation of disease models
  • Maximum tolerated dose studies
  • Dose range finding
  • Efficacy studies

CNS/PNS Models

  • Alzheimer’s disease
  • Memory impairment
  • Seizure
  • Parkinson’s disease
  • EAE model
  • Depression, anxiety and schizophrenia
  • LPS-induced neuroinflammation
  • Migraine
  • Other neurodegenerative diseases

Analytical Platforms

  • Drug exposure in blood and tissue
  • Specific biomarkers in blood and tissue levels
  • Gene or protein analysis platforms
  • FACS analysis of cells, blood and tissue samples
  • Histology, biochemistry, IHC
  • Blood sample analysis with biochemistry and hematology
  • Analysis of body fluid, urine and feces