A modern, well-lit lab showcasing DMPK services. Two individuals in lab coats work with high-tech bioanalytical instruments, highlighting the clean, organized, and advanced environment.

DMPK Services

Pharmaron’s DMPK services support the needs for small molecule drug discovery, preclinical and clinical development, including preclinical candidate (PCC) identification and nomination, Investigational New Drug (IND) enabling and New Drug Application (NDA) packaging for regulatory submission. DMPK services are offered from our sites in China, United Kingdom and the United States.

Pharmaron’s DMPK group offers comprehensive in vitro ADME, radiolabelled metabolism, in vitro toxicity and in vivo pharmacokinetics services, which allow for the evaluation of DMPK properties and toxicity of small molecule drug candidates with high data quality in a cost-effective manner.

Appreciating that in vitro ADME screening and in vivo pharmacokinetic studies are at the heart of drug discovery decision making, we offer these services with a delivery time of 5 to 10 days.

Furthermore, our DMPK division in the US provides standard services via our E-store.

Explore our on-demand DMPK webinars and podcasts, covering a spectrum of insightful DMPK topics.

Close-up of a blue mass spectrometer in a laboratory setting focused on bioanalytical development. The device features various connectors, wires, and a metallic cylindrical component attached to its front. The background shows partially visible lab equipment, indicating a scientific environment.

in vitro ADME

  • Physical chemical properties
  • Drug absorption & transport
  • Drug metabolism
  • Drug-drug interactions
A researcher in a lab coat and face mask uses a computer to analyze data related to genetic toxicology displayed on the monitor. Through a window in the background, another scientist operates a microscope. The lab environment appears clean and well-lit. The word "Pharmaron" is visible on the window.

in vitro Toxicity

  • Liver toxicity package (general and mechanistic toxicity evaluation)
  • Phototoxicity (3T3 NRU)
  • Cardiotoxicity
  • Genotoxicity
A close-up of a laboratory automated machine with a robotic arm placing a white tray or plate into a holder. The machinery, crucial for genetic toxicology studies, is metallic with some orange and white parts. The background is blurred, emphasizing the equipment's intricate details.

in vivo PK

  • Formulation screening
  • Standard and special PK
  • Excretion balance
  • Tissue distribution
  • Metabolite quantification
Close-up of a laboratory device with a screen displaying data and a control panel. The device, utilized for bioanalytical development, features a label reading "+Lab ngenious" in English and Chinese characters on the side. The surroundings indicate a modern, high-tech laboratory setting.


  • Calibrated assays for better in vitro-in vivo correlation and human dose prediction
  • Comprehensive transporter platform; permeability/absorption models
  • Validated 3D models for evaluation of absorption and liver toxicity
  • in vitro liver toxicity platform to evaluate DILI risk at an early stage
  • Fully integrated automated ADME screening
lab chemistry beaker

Radiolabelled Metabolism

  • in vitro Metabolism using 14C- and 3H-labelled compounds
  • Tissue distribution and excretion using QWBA and mARG


  • LC-MS/MS
  • Fully integrated automation
  • Liquid handlers
  • Multifunctional detectors
  • Radioactivity detectors

Download an Overview of Pharmaron’s DMPK Capabilities

A slide with the title "DMPK - Discovery through Clinical." It includes a detailed document outlining service capabilities like preclinical ADME studies and specialties on the left side, set against a blue geometric background. The Pharmaron logo is displayed at the bottom right corner.