DMPK Services

Pharmaron’s DMPK services support the needs for small molecule drug discovery, preclinical and clinical development, including preclinical candidate (PCC) identification and nomination, Investigational New Drug (IND) enabling and New Drug Application (NDA) packaging for regulatory submission. DMPK services are offered from our sites in China, United Kingdom and the United States.

Pharmaron’s DMPK group offers comprehensive in vitro ADME, radiolabelled metabolism, in vitro toxicity and in vivo pharmacokinetics services, which allow for the evaluation of DMPK properties and toxicity of small molecule drug candidates with high data quality in a cost-effective manner.

Our US Lab Services team provides express DMPK services that offer optimized, screening-based protocols with deliverables in 5-10 business days. For definitive studies to support regulatory approval, or to customize our online store assays, visit our E-Store.

Explore our on-demand DMPK webinars and podcasts, covering a spectrum of insightful DMPK topics.

Pharmaron’s DMPK Webinar Series Library

Pharmaron’s DMPK Insights Podcast Series

Capabilities

Discovery DMPK

Regulatory DMPK

Radiolabelled Metabolism and Biodistribution

US Lab Services DMPK E-Store

in vitro ADME

Physical chemical properties
Drug absorption & transport
Drug metabolism
Drug-drug interactions

in vitro Toxicity

Liver toxicity package (general and mechanistic toxicity evaluation)
Phototoxicity (3T3 NRU)
Cardiotoxicity
Genotoxicity

in vivo PK

Formulation screening
Standard and special PK
Excretion balance
Tissue distribution
Metabolite quantification

Specialties

Calibrated assays for better in vitro-in vivo correlation and human dose prediction
Comprehensive transporter platform; permeability/absorption models
Validated 3D models for evaluation of absorption and liver toxicity
in vitro liver toxicity platform to evaluate DILI risk at an early stage
Fully integrated automated ADME screening