Inflammation and Pain Animal Models

Inflammation and Pain Animal Model Services

Our in vivo pharmacology team is experienced with inflammation and pain disease animal model establishment and validation for efficacy screening, in vivo pharmacology profiling, PDPK and MOA studies.

The team is supported by internal PK/bioanalytical, ex vivo pharmacology and in vitro biology teams to provide integrated services.

Study Types

  • Development and validation of disease models
  • Maximum tolerated dose studies
  • Dose range finding studies
  • Efficacy studies

Neuropathic Pain Models

  • Chronic Constriction Injury (CCI: Bennett Model)
  • Spared Nerve Injury (SNI) model
  • Sciatic Nerve Clamping Injury (SNCI)
  • Vincristine induced peripheral neuropathic pain
  • Bortizomib induced peripheral neuropathy pain
  • Paclitaxel induced peripheral neuropathy pain
  • Cancer pain model: Cancer induced bone pain

Analytical Platforms

  • Drug exposure in blood and tissue
  • Specific biomarkers in blood and tissue levels
  • Gene or protein analysis platforms
  • FACS analysis of cells, blood and tissue samples
  • Histology, biochemistry, IHC
  • Blood sample analysis with biochemistry and hematology
  • Analysis of body fluid, urine and feces

Inflammation and PK/PD Models

  • Carrageenan
  • LPS-induced cytokine release model
  • CFA
  • Delayed-Type Hypersensitivity
  • NGF
  • Tail flicks
  • Formalin
  • Wound healing
  • Paw incision
  • Air pouch
  • AcOH induced writhing model
  • Passive Cutaneous Anaphylaxis (PCA)

Additional Inflammation and PK/PD Models

  • DS-induced colitis
  • Rotorod assay
  • CLP
  • Diuretic assay
  • Cytokine release animal model
  • Adjuvant-Induced Arthritis
  • Mono Iodoacetate-Induced
  • Type II Collagen-Induced Arthritis (CIA)
  • Monosodium urate (MSU) crystals-induced gout arthritis
  • Adenine and Oxonate induced gout model