Carbon-14 Radiolabels and AMS for Biologics
Carbon-14 Radiolabels and AMS for Biologics Services
On occasion there can be quantitative challenges with existing analytical methods for detection of biologics and other large molecules at very low LOQs. Pharmaron can employ Accelerator Mass Spectrometry (AMS) with 14C to help resolve such limitations with LC-MS/MS and immunoassay bioanalytical methods.
Pharmaron’s team can radiolabel biologics with 14C then utilize Accelerator Mass Spectrometry (AMS) analysis to provide pharmacokinetic (PK) and tissue disposition data in a wide range of animal models.
LC+AMS Bioanalysis and Total [14C] by AMS for Biologics including Potent Compounds
- ADCs
- Oligonucleotides
- Fusion proteins
- Peptides
- Polymers
[14C] Radioisotopic Analysis of Parent/Metabolite(s) in a Wide Range of Biological Matrices
- Blood
- Plasma
- Excreta
- Bile
- CSF
- Expired air
- Skin
- Kidney
- Liver
- Spleen
- Biopsy tissue
- Cells e.g. PBMCs
Target Turnover Studies
- Assess “drugability” of therapeutic targets in preclinical models
- 14C radiolabelled proteins and cytokines
- Targeting of tumor tissues in disease models
Capabilities
