Protein Science

Pharmaron offers services for a wide range of custom antibody, protein, and peptide expression, from research-grade drug target proteins to first-in-class bi-specific therapeutic antibodies and nanobodies.

Together with our comprehensive in vitro biology and in vivo pharmacology experience, Pharmaron can be an integral partner at multiple stages of your early biologics research and development programs. Our services can also express antibodies and proteins as reagents to support in vitro biology assay development needs.

• Transient and stable cell line generation
• Molecular biology services: molecular cloning, mutagenesis methods, RNA/DNA extraction, cDNA library generation 
• Recombinant protein/antibody expression
• Protein expression systems: mammalian, bacterial, insect, yeast
• Purification services
• Binding Screening – LC-MS to identify covalent binding through changes in intact mass
• Analysis – Ultra HPLC, capillary electrophoresis (CE-SDS, CE-CZE, CE-CIEF, CE-glycan analysis), mass-spec (intact protein, reduced protein, glycan analysis and peptide mapping, and protein modifications) and various imaging analysis systems to confirm synthesized product 
• Molecule-molecule (small-large and large-large molecules) interaction/binding analysis – HTS with surface plasmon resonance (SPR) technology to provide quantitative kinetic analysis