Accelerator Mass Spectrometry (AMS)

Accelerator Mass Spectrometry (AMS) Services
Pharmaron is the recognized leader in using Accelerator Mass Spectrometry (AMS) technology. Our team is primarily focused on pharmaceutical and biopharmaceutical R&D, employing Accelerator Mass Spectrometry (AMS) as a unique, alternative, ultra-sensitive 14C analytical tool to support both clinical and non-clinical metabolism programs. In addition to the typical AMS study designs below, Pharmaron can offer unique solutions to specific compound-related questions.
Advantages of using AMS technology include ultra-sensitive LLOQs (sub-pg equivalents per mL), no matrix interference and no sample carryover for the graphitization process.
Standard Clinical Designs:
- Mass balance and total [14C] by AMS (total radioactivity levels)
- Metabolite profiling by LC fractionation with detection by AMS
- Absolute bioavailability (IVPK) – IV 14C-microtracer by validated LC-AMS bioanalytical assay
- 14C dose solution analysis for low specific activity 14C dose preparations
Capabilities

Instrumentation and Software
- SS-AMS 250 kV NEC Accelerator Mass Spectrometer (AMS)
- Liquid Scintillation Counters (TriCarb 5110 TR)
- PerkinElmer Model 30 Oxidizers
- ThermoFisher FlashSmart CHN Analyzer
- Agilent 1290 HP(UP)LC’s / OpenLab CDS
- LabLogic Beta-RAM Flow-through Radio Detectors
- Perkin Elmer MicroBeta Scintillation Counter
- LabLogic Debra® (LIMS)
- Lablogic Laura® (CDS and data analysis)
- Lablogic Stacy® (Sample inventory)
