Accelerator Mass Spectrometry (AMS)

Accelerator Mass Spectrometry (AMS) Services

Pharmaron is the recognized leader in using Accelerator Mass Spectrometry (AMS) technology. Our team is primarily focused on pharmaceutical and biopharmaceutical R&D, employing Accelerator Mass Spectrometry (AMS) as a unique, alternative, ultra-sensitive 14C analytical tool to support both clinical and non-clinical metabolism programs. In addition to the typical AMS study designs below, Pharmaron can offer unique solutions to specific compound-related questions.

Advantages of using AMS technology include ultra-sensitive LLOQs (sub-pg equivalents per mL), no matrix interference and no sample carryover for the graphitization process.

Standard Clinical Designs:

  • Mass balance and total [14C] by AMS (total radioactivity levels)
  • Metabolite profiling by LC fractionation with detection by AMS
  • Absolute bioavailability (IVPK) – IV 14C-microtracer by validated LC-AMS bioanalytical assay
  • 14C dose solution analysis for low specific activity 14C dose preparations

Pharmaron Fraction Collector

Instrumentation and Software

  • SS-AMS 250 kV NEC Accelerator Mass Spectrometer (AMS)
  • Liquid Scintillation Counters (TriCarb 5110 TR)
  • PerkinElmer Model 30 Oxidizers
  • ThermoFisher FlashSmart CHN Analyzer
  • Agilent 1290 HP(UP)LC’s / OpenLab CDS
  • LabLogic Beta-RAM Flow-through Radio Detectors
  • Perkin Elmer MicroBeta Scintillation Counter
  • LabLogic Debra® (LIMS) 
  • Lablogic Laura® (CDS and data analysis) 
  • Lablogic Stacy® (Sample inventory)